Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | KDM5C | P41229 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | PTGIR | P43119 | 1/20 | 0.36 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 3/20 | 0.33 |
| ▸ | CDK8 | P49336 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11086352 | 0.84 | NPC1 (0.43) | MKNK1MKNK2ALDH1A1PTGIRSMN1; SMN2 | |
| SCHEMBL5790683 | 0.72 | SIGMAR1 (0.45) | SRD5A2OPRD1ALDH1A1SIGMAR1REN | |
| SCHEMBL7388960 | 0.69 | ALDH1A1 (0.61) | SRD5A2ALDH1A1SIGMAR1POLBSMN1; SMN2 | |
| SCHEMBL25753684 | 0.67 | POLB (0.46) | MKNK1MKNK2POLBSMN1; SMN2 | |
| SCHEMBL23140495 | 0.66 | SIGMAR1 (0.76) | MKNK1MKNK2OPRD1ALDH1A1SIGMAR1 | |
| SCHEMBL2192774 | 0.65 | PTGIR (0.51) | ALDH1A1PTGIRHDAC6POLB | |
| SCHEMBL4820083 | 0.64 | CYP3A4 (0.55) | MKNK1MKNK2ALDH1A1 | |
| SCHEMBL28185115 | 0.64 | P2RX7 (0.38) | MKNK1MKNK2ALDH1A1POLB | |
| SCHEMBL15824964 | 0.64 | MKNK1 (0.50) | MKNK1MKNK2ALDH1A1SIGMAR1REN | |
| Hydrochloric Acid SCHEMBL20236368 | 0.63 | LTB4R2 (0.49) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4439606-A | ANTICHOLESTEROL, ANTILIPEMIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1984-03-27 | — | — | US | claimed |
| US-4439606-A | ANTICHOLESTEROL, ANTILIPEMIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1984-03-27 | — | — | US | disclosed |
| EP-0094498-A2 | Antiatherosclerotic 1-piperazine derivatives | AMERICAN CYANAMID COMPANY (US) | 1983-11-23 | — | — | EP | disclosed |