SCHEMBL11076649

SCHEMBL11076649

COc1cccc([C@@]23CCN(C)C(=O)[C@@H]2CCC(=O)C3)c1

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 3/20 0.49
SLC6A4 P31645 2/20 0.45
SLC6A2 P23975 1/20 0.44
SLC6A3 Q01959 1/20 0.44
BACE1 P56817 2/20 0.43
CTSD P07339 1/20 0.43
CTSE P14091 1/20 0.43
ALDH1A1 P00352 1/20 0.42
OPRM1 P35372 3/20 0.42
OPRD1 P41143 2/20 0.42
OPRK1 P41145 2/20 0.42
KMT2A Q03164 1/20 0.41
MAPT P10636 1/20 0.41
SLC6A9 P48067 1/20 0.40
GAA P10253 1/20 0.39
DDB1 Q16531 2/20 0.39
CRBN Q96SW2 2/20 0.39
OPRL1 P41146 1/20 0.39
BACE2 Q9Y5Z0 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11079211 1.00 SIGMAR1 (0.49) SIGMAR1SLC6A4SLC6A2SLC6A3BACE1
SCHEMBL11076652 1.00 SIGMAR1 (0.49) SIGMAR1SLC6A4SLC6A2SLC6A3BACE1
SCHEMBL8656342 0.81 SLC6A4 (0.58) SIGMAR1SLC6A4SLC6A2SLC6A3BACE1
SCHEMBL11391861 0.81 SLC6A4 (0.58) SIGMAR1SLC6A4SLC6A2SLC6A3BACE1
SCHEMBL8434553 0.81 SLC6A4 (0.58) SIGMAR1SLC6A4SLC6A2SLC6A3BACE1
SCHEMBL7699893 0.81 SLC6A4 (0.58) SIGMAR1SLC6A4SLC6A2SLC6A3BACE1
SCHEMBL11550690 0.80 SLC6A4 (0.56) SIGMAR1SLC6A4SLC6A2SLC6A3BACE1
SCHEMBL11550220 0.80 SLC6A4 (0.56) SIGMAR1SLC6A4SLC6A2SLC6A3BACE1
SCHEMBL11550223 0.80 SLC6A4 (0.56) SIGMAR1SLC6A4SLC6A2SLC6A3BACE1
Ethylene SCHEMBL11397601 0.80 OPRM1 (0.56) SIGMAR1SLC6A4SLC6A2SLC6A3BACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4435572-A FROM 3-METHOXYBENZALDEHYDE THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1984-03-06 US disclosed
US-4346224-A MORPHINE ANALOGS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1982-08-24 US disclosed
US-4289882-A MORPHINE ANALOG ANALGESICS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH & HUMAN SERVICES (US) 1981-09-15 US disclosed
US-4189583-A FROM 1-METHYL-2-OXO-3-METHYLENE-4-(3'-METHOXYPHENYL)-4 -(CARBOXYMETHYLENE)PIPERIDINE BY CYCLIZATION THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) 1980-02-19 US disclosed