Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CASR | P41180 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11078342 | 0.92 | TLR8 (0.54) | TLR8TSHRTLR7ALDH1A1KDM4E | |
| SCHEMBL11079355 | 0.88 | ALDH1A1 (0.55) | TLR8TSHRTLR7ALDH1A1CASR | |
| SCHEMBL11077028 | 0.86 | NLRP3 (0.55) | TLR8TSHRTLR7ALDH1A1KDM4E | |
| SCHEMBL28288759 | 0.84 | TLR8 (0.51) | TLR8TSHRTLR7ALDH1A1CASR | |
| SCHEMBL6917380 | 0.78 | CASR (0.56) | TLR8TSHRTLR7ALDH1A1CASR | |
| SCHEMBL9611690 | 0.78 | TLR7 (0.61) | TLR8TSHRTLR7ALDH1A1KDM4E | |
| SCHEMBL17819055 | 0.77 | TLR8 (1.00) | TLR8CNR1CNR2 | |
| SCHEMBL11435483 | 0.76 | PTGER4 (0.51) | TLR8ALDH1A1KDM4EHPGDTP53 | |
| SCHEMBL9321137 | 0.76 | TP53 (0.72) | TLR8TSHRALDH1A1KDM4EHPGD | |
| SCHEMBL11076799 | 0.75 | CASR (0.50) | TLR8TSHRALDH1A1CASRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4435417-A | ANTIINFLAMMATORY AGENTS | GRUPPO LEPETIT S.P.A. (IT) | 1984-03-06 | — | — | US | disclosed |
| EP-0012866-A1 | New 3H-naphtho(1,2-d)imidazoles, processes for preparing them, compounds for use as antiinflammatory and antimicrobial agents and compositions for that use containing them | GRUPPO LEPETIT S.P.A. (IT) | 1980-07-09 | — | — | EP | disclosed |