Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.54 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11076876 | 0.92 | TLR8 (0.62) | TLR8ADORA2BADORA2AADORA3ADORA1 | |
| SCHEMBL11077028 | 0.88 | NLRP3 (0.55) | TLR8ADORA2BADORA2AADORA3ADORA1 | |
| SCHEMBL9611690 | 0.80 | TLR7 (0.61) | TLR8ADORA2BADORA2AADORA3ADORA1 | |
| SCHEMBL11079355 | 0.80 | ALDH1A1 (0.55) | TLR8KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11435483 | 0.78 | PTGER4 (0.51) | TLR8KDM4EALDH1A1HPGDCYP2C9 | |
| SCHEMBL28288759 | 0.76 | TLR8 (0.51) | TLR8KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11079618 | 0.76 | GRIK2 (0.52) | TLR8KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11083637 | 0.76 | ALDH1A1 (0.62) | TLR8KDM4EALDH1A1HPGDCYP2C9 | |
| SCHEMBL11078753 | 0.76 | TLR8 (0.44) | TLR8ADORA2BADORA2AADORA3ADORA1 | |
| SCHEMBL11026052 | 0.76 | ALDH1A1 (0.50) | KDM4EALDH1A1HPGDHSD17B10TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4435417-A | ANTIINFLAMMATORY AGENTS | GRUPPO LEPETIT S.P.A. (IT) | 1984-03-06 | — | — | US | disclosed |