Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 6/20 | 0.38 |
| ▸ | HTR2B | P41595 | 5/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27613840 | 0.83 | HTR3E (0.45) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL653537 | 0.81 | MC4R (0.41) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL1012668 | 0.81 | MC4R (0.41) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL7258181 | 0.80 | ADRB1 (0.43) | ADRB1 | |
| SCHEMBL21382496 | 0.80 | SLC6A2 (0.34) | ADRB1HTR2CHTR2BHTR2A | |
| SCHEMBL23244311 | 0.78 | PKM (0.42) | MEN1KMT2A | |
| SCHEMBL27744342 | 0.76 | HTR3E (0.41) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL10683759 | 0.75 | ADRB1 (0.56) | ADRB1MEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL1013575 | 0.74 | F2 (0.41) | CNR2CNR1CYP2C8CYP2C9CYP2C19 | |
| SCHEMBL11983448 | 0.74 | CNR2 (0.55) | CNR2CNR1CYP2C8CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4439606-A | ANTICHOLESTEROL, ANTILIPEMIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1984-03-27 | — | — | US | disclosed |
| EP-0094498-A2 | Antiatherosclerotic 1-piperazine derivatives | AMERICAN CYANAMID COMPANY (US) | 1983-11-23 | — | — | EP | disclosed |