SCHEMBL1107830

SCHEMBL1107830

FC(F)(F)c1cc(CC(NC2=NCCS2)c2cccc(Cl)c2Cl)cc(C(F)(F)F)c1

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.39
MAPT P10636 2/20 0.39
NPC1 O15118 3/20 0.38
POLB P06746 2/20 0.35
HPGD P15428 1/20 0.34
KMT2A Q03164 5/20 0.34
MEN1 O00255 4/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
LMNA P02545 3/20 0.34
TAAR1 Q96RJ0 1/20 0.34
P2RX7 Q99572 1/20 0.34
RAB9A P51151 2/20 0.33
TACR1 P25103 1/20 0.33
ALDH1A1 P00352 1/20 0.32
GAA P10253 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1107847 0.86 ATM (0.43) ATMMAPTNPC1POLBHPGD
SCHEMBL1096470 0.84 ATM (0.41) ATMMAPTNPC1POLBKMT2A
SCHEMBL1107831 0.84 MAPT (0.41) ATMMAPTNPC1POLBHPGD
SCHEMBL14000969 0.83 ATM (0.41) ATMMAPTNPC1POLBHPGD
SCHEMBL14000960 0.82 ATM (0.43) ATMMAPTNPC1POLBHPGD
SCHEMBL14000967 0.80 ATM (0.40) ATMMAPTNPC1POLBHPGD
SCHEMBL1107861 0.80 KMT2A (0.37) ATMMAPTNPC1KMT2AMEN1
SCHEMBL1107802 0.80 NPC1 (0.41) ATMMAPTNPC1POLBHPGD
SCHEMBL1107815 0.79 NPC1 (0.40) ATMMAPTNPC1KMT2AMEN1
SCHEMBL14000958 0.79 ATM (0.41) ATMMAPTPOLBKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8153560-B2 Pesticidal active mixtures comprising aminothiazoline compounds BASF SE (DE) 2012-04-10 US disclosed
US-8153560-B2 Pesticidal active mixtures comprising aminothiazoline compounds BASF SE (DE) 2012-04-10 US disclosed
US-20100056469-A1 Pesticidal Active Mixtures Comprising Aminothiazoline Compounds BASF SE (DE) 2010-03-04 US disclosed
US-20100056469-A1 Pesticidal Active Mixtures Comprising Aminothiazoline Compounds BASF SE (DE) 2010-03-04 US disclosed
WO-2008104503-A1 PESTICIDAL ACTIVE MIXTURES COMPRISING AMINOTHIAZOLINE COMPOUNDS BASF SE (DE) 2008-09-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100056469-A1 Pesticidal Active Mixtures Comprising Aminothiazoline Compounds ACHE, PTMS, CHRM3 ATM 917/4885MAPT 2950/4885NPC1 2442/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.