SCHEMBL1107861

SCHEMBL1107861

Cc1cc(C)cc(CC(NC2=NCCS2)c2cccc(C(F)(F)F)c2Cl)c1

nearest known ligand 0.37

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.37
P2RX7 Q99572 2/20 0.37
NPC1 O15118 7/20 0.36
RAB9A P51151 6/20 0.36
KDM4E B2RXH2 2/20 0.36
LMNA P02545 1/20 0.35
TAAR1 Q96RJ0 1/20 0.35
SMN1; SMN2 Q16637 4/20 0.35
ATM Q13315 1/20 0.34
ALDH1A1 P00352 3/20 0.33
MAPT P10636 2/20 0.33
MEN1 O00255 2/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1107882 0.90 KMT2A (0.38) KMT2ANPC1RAB9AKDM4ELMNA
SCHEMBL1107840 0.89 KMT2A (0.38) KMT2ANPC1RAB9AKDM4ELMNA
SCHEMBL1096470 0.87 ATM (0.41) KMT2ANPC1RAB9AKDM4ELMNA
SCHEMBL1107816 0.85 KMT2A (0.36) KMT2ANPC1RAB9AKDM4ELMNA
SCHEMBL14095777 0.84 SMN1; SMN2 (0.37) KMT2ANPC1RAB9AKDM4ELMNA
SCHEMBL1107802 0.82 NPC1 (0.41) KMT2ANPC1RAB9ALMNATAAR1
SCHEMBL1107853 0.81 NPC1 (0.39) KMT2ANPC1RAB9AKDM4ELMNA
SCHEMBL229249 0.80 RAB9A (0.40) KMT2ANPC1RAB9AKDM4ELMNA
SCHEMBL14095776 0.80 NPC1 (0.42) KMT2ANPC1RAB9AKDM4ELMNA
SCHEMBL1107830 0.80 ATM (0.39) KMT2AP2RX7NPC1RAB9ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8153560-B2 Pesticidal active mixtures comprising aminothiazoline compounds BASF SE (DE) 2012-04-10 US disclosed
US-8153560-B2 Pesticidal active mixtures comprising aminothiazoline compounds BASF SE (DE) 2012-04-10 US disclosed
US-20100056469-A1 Pesticidal Active Mixtures Comprising Aminothiazoline Compounds BASF SE (DE) 2010-03-04 US disclosed
US-20100056469-A1 Pesticidal Active Mixtures Comprising Aminothiazoline Compounds BASF SE (DE) 2010-03-04 US disclosed
WO-2008104503-A1 PESTICIDAL ACTIVE MIXTURES COMPRISING AMINOTHIAZOLINE COMPOUNDS BASF SE (DE) 2008-09-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100056469-A1 Pesticidal Active Mixtures Comprising Aminothiazoline Compounds ACHE, PTMS, CHRM3 KMT2A 1324/4885P2RX7 775/4885NPC1 2442/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.