SCHEMBL1096470

SCHEMBL1096470

Cc1cc(C)cc(CC(NC2=NCCS2)c2cccc(Cl)c2Cl)c1

nearest known ligand 0.41

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.41
NPC1 O15118 6/20 0.39
RAB9A P51151 6/20 0.39
KDM4E B2RXH2 1/20 0.39
LMNA P02545 1/20 0.38
TAAR1 Q96RJ0 1/20 0.38
MAPT P10636 1/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
ALDH1A1 P00352 1/20 0.38
POLB P06746 1/20 0.36
MEN1 O00255 3/20 0.36
KMT2A Q03164 3/20 0.36
L3MBTL1 Q9Y468 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
PKM P14618 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14000969 0.90 ATM (0.41) ATMNPC1RAB9AKDM4ELMNA
SCHEMBL1107847 0.89 ATM (0.43) ATMNPC1RAB9AKDM4ELMNA
SCHEMBL1107861 0.87 KMT2A (0.37) ATMNPC1RAB9AKDM4ELMNA
SCHEMBL14000949 0.85 ATM (0.39) ATMNPC1RAB9AKDM4ELMNA
SCHEMBL229249 0.84 RAB9A (0.40) NPC1RAB9AKDM4ELMNATAAR1
SCHEMBL1107842 0.84 KMT2A (0.46) ATMNPC1RAB9AKDM4ELMNA
SCHEMBL14000960 0.84 ATM (0.43) ATMNPC1RAB9AKDM4ELMNA
SCHEMBL1107830 0.84 ATM (0.39) ATMNPC1RAB9ALMNATAAR1
SCHEMBL1107831 0.84 MAPT (0.41) ATMNPC1RAB9ALMNATAAR1
SCHEMBL14000951 0.84 ATM (0.38) ATMNPC1RAB9AKDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2176232-B1 1-(AZOLIN-2-YL)AMINO-1,2-DIPHENYLETHANE COMPOUNDS FOR COMBATING ANIMAL PESTS BASF SE (DE) 2013-06-19 EP disclosed
EP-2176232-B1 1-(AZOLIN-2-YL)AMINO-1,2-DIPHENYLETHANE COMPOUNDS FOR COMBATING ANIMAL PESTS BASF SE (DE) 2013-06-19 EP disclosed
US-8211924-B2 1-(azolin-2-yl)amino-1,2-diphenylethane compounds for combating animal pests BASF SE (DE) 2012-07-03 US disclosed
US-8211924-B2 1-(azolin-2-yl)amino-1,2-diphenylethane compounds for combating animal pests BASF SE (DE) 2012-07-03 US disclosed
US-8211924-B2 1-(azolin-2-yl)amino-1,2-diphenylethane compounds for combating animal pests BASF SE (DE) 2012-07-03 US disclosed
US-8153560-B2 Pesticidal active mixtures comprising aminothiazoline compounds BASF SE (DE) 2012-04-10 US disclosed
US-8153560-B2 Pesticidal active mixtures comprising aminothiazoline compounds BASF SE (DE) 2012-04-10 US disclosed
US-8153560-B2 Pesticidal active mixtures comprising aminothiazoline compounds BASF SE (DE) 2012-04-10 US disclosed
US-20100280078-A1 1-(Azolin-2-yl)amino-1,2-diphenylethane compounds for combating animal pests BASF SE (DE) 2010-11-04 US disclosed
US-20100280078-A1 1-(Azolin-2-yl)amino-1,2-diphenylethane compounds for combating animal pests BASF SE (DE) 2010-11-04 US disclosed
US-20100280078-A1 1-(Azolin-2-yl)amino-1,2-diphenylethane compounds for combating animal pests BASF SE (DE) 2010-11-04 US disclosed
EP-2176232-A1 1-(AZOLIN-2-YL)AMINO-1,2-DIPHENYLETHANE COMPOUNDS FOR COMBATING ANIMAL PESTS BASF SE (DE) 2010-04-21 EP disclosed
US-20100056469-A1 Pesticidal Active Mixtures Comprising Aminothiazoline Compounds BASF SE (DE) 2010-03-04 US disclosed
US-20100056469-A1 Pesticidal Active Mixtures Comprising Aminothiazoline Compounds BASF SE (DE) 2010-03-04 US disclosed
US-20100056469-A1 Pesticidal Active Mixtures Comprising Aminothiazoline Compounds BASF SE (DE) 2010-03-04 US disclosed
EP-2063711-A1 PESTICIDAL ACTIVE MIXTURES COMPRISING AMINOTHIAZOLINE COMPOUNDS BASF SE (DE) 2009-06-03 EP disclosed
WO-2009004032-A1 1-(AZOLIN-2-YL)AMINO-1,2-DIPHENYLETHANE COMPOUNDS FOR COMBATING ANIMAL PESTS BASF SE (DE) 2009-01-08 WO disclosed
WO-2009004032-A1 1-(AZOLIN-2-YL)AMINO-1,2-DIPHENYLETHANE COMPOUNDS FOR COMBATING ANIMAL PESTS BASF SE (DE) 2009-01-08 WO disclosed
WO-2008104503-A1 PESTICIDAL ACTIVE MIXTURES COMPRISING AMINOTHIAZOLINE COMPOUNDS BASF SE (DE) 2008-09-04 WO disclosed
WO-2008104503-A1 PESTICIDAL ACTIVE MIXTURES COMPRISING AMINOTHIAZOLINE COMPOUNDS BASF SE (DE) 2008-09-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100280078-A1 1-(Azolin-2-yl)amino-1,2-diphenylethane compounds for combating animal pests NR0B1, NR0B2, NR2C2 ATM 3656/4885NPC1 756/4885RAB9A 1282/4885
US-20100056469-A1 Pesticidal Active Mixtures Comprising Aminothiazoline Compounds ACHE, PTMS, CHRM3 ATM 917/4885NPC1 2442/4885RAB9A 2591/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.