Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | AGPAT2 | O15120 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11071524 | 0.91 | OPRM1 (0.42) | TSHROPRM1OPRL1SLC6A4SLC6A3 | |
| SCHEMBL11066779 | 0.88 | TSHR (0.36) | TSHROPRM1OPRL1SLC6A4SLC6A3 | |
| SCHEMBL11066917 | 0.88 | HTT (0.36) | TSHRMAPTOPRM1OPRL1SLC6A4 | |
| SCHEMBL11079248 | 0.88 | SLC6A4 (0.36) | TSHRMAPTSLC6A4SLC6A3MEN1 | |
| SCHEMBL11072624 | 0.86 | TSHR (0.35) | TSHRMAPTSLC6A4SLC6A3MEN1 | |
| SCHEMBL11071790 | 0.86 | TSHR (0.36) | TSHRMAPTSLC6A4SLC6A3MEN1 | |
| SCHEMBL11069371 | 0.85 | TSHR (0.35) | TSHRMAPTSLC6A4SLC6A3MEN1 | |
| SCHEMBL11075481 | 0.83 | OPRM1 (0.38) | TSHROPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL11068867 | 0.82 | CRHR1 (0.34) | TSHR | |
| SCHEMBL11071584 | 0.80 | MEN1 (0.39) | TSHRSLC6A4SLC6A3MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4447454-A | Analgetic compounds, compositions and process of treatment | THE UPJOHN COMPANY (US) | 1984-05-08 | — | — | US | disclosed |
| US-4113866-A | ANALGETIC COMPOUNDS, COMPOSITIONS AND PROCESS OF TREATMENT | THE UPJOHN COMPANY (US) | 1978-09-12 | — | — | US | disclosed |