Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 8/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11068867 | 0.94 | CRHR1 (0.34) | TSHRCRHR1 | |
| SCHEMBL11071790 | 0.93 | TSHR (0.36) | TSHRCRHR1ALDH1A1KMT2AMEN1 | |
| SCHEMBL11074056 | 0.91 | CRHR1 (0.33) | TSHRCRHR1 | |
| SCHEMBL11071588 | 0.89 | CRHR1 (0.34) | TSHRCRHR1NPSR1KMT2AMEN1 | |
| SCHEMBL11072624 | 0.86 | TSHR (0.35) | TSHRMAPK1KMT2AMEN1MAPT | |
| SCHEMBL11078728 | 0.85 | TSHR (0.35) | TSHRKMT2AMEN1MAPTSLC6A4 | |
| SCHEMBL11071524 | 0.84 | OPRM1 (0.42) | TSHRSLC6A4SLC6A3 | |
| SCHEMBL11081480 | 0.84 | CRHR1 (0.33) | CRHR1 | |
| SCHEMBL11079248 | 0.83 | SLC6A4 (0.36) | TSHRALDH1A1CYP2D6CYP2C9KMT2A | |
| SCHEMBL11076403 | 0.83 | CRHR1 (0.35) | TSHRCRHR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4447454-A | Analgetic compounds, compositions and process of treatment | THE UPJOHN COMPANY (US) | 1984-05-08 | — | — | US | disclosed |
| US-4113866-A | ANALGETIC COMPOUNDS, COMPOSITIONS AND PROCESS OF TREATMENT | THE UPJOHN COMPANY (US) | 1978-09-12 | — | — | US | disclosed |