Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 3/20 | 0.36 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556355 | 0.81 | HTR1A (0.55) | HTR1ADRD2HTR2CHRH1HTR7 | |
| SCHEMBL9441347 | 0.80 | HTR1A (0.54) | HTR1ADRD2HTR2CHRH1HTR7 | |
| SCHEMBL9441283 | 0.80 | HTR1A (0.54) | HTR1ADRD2HTR2CHRH1HTR7 | |
| SCHEMBL11085047 | 0.78 | HTR1A (0.39) | HTR1ADRD2HTR2CHRH1HTR7 | |
| SCHEMBL7304949 | 0.71 | HTR1A (0.52) | HTR1ADRD2HTR2CHRH1HTR7 | |
| SCHEMBL10973154 | 0.70 | FAAH (0.46) | HTR1AHTR7MGLLFAAH | |
| Hydrochloric Acid SCHEMBL11174994 | 0.70 | HTR1A (0.74) | HTR1ADRD2HTR2CHRH1HTR7 | |
| SCHEMBL10469856 | 0.70 | HTR1A (0.39) | HTR1ADRD2HTR2CHRH1HTR7 | |
| SCHEMBL14359059 | 0.70 | HTR1A (0.44) | HTR1ADRD2HTR2CHRH1HTR7 | |
| SCHEMBL9035109 | 0.70 | HTR1A (0.51) | HTR1ADRD2HTR2CHRH1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452799-A | NEUROLEPTIC AGENTS | MEAD JOHNSON & COMPANY (US) | 1984-06-05 | — | — | US | disclosed |
| US-4423049-A | TRANQUILIZERS | MEAD JOHNSON & COMPANY (US) | 1983-12-27 | — | — | US | disclosed |
| US-4411901-A | ANTIPSYCHOTICS | MEAD JOHNSON & COMPANY (US) | 1983-10-25 | — | — | US | disclosed |
| US-4361565-A | PSYCHOTROPIC PROPERTIES | MEAD JOHNSON & COMPANY (US) | 1982-11-30 | — | — | US | disclosed |