Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | HTR2C | P28335 | 3/20 | 0.44 |
| ▸ | HRH1 | P35367 | 3/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14359278 | 0.80 | HTR1A (0.36) | HTR1ADRD2HTR2CHRH1HTR2A | |
| SCHEMBL8295323 | 0.80 | KDM4E (0.48) | HTR1ADRD2HTR2CHRH1HTR2A | |
| SCHEMBL14359548 | 0.78 | CHRM2 (0.35) | HTR1ADRD2HTR2CHRH1HTR2A | |
| SCHEMBL8349046 | 0.75 | LMNA (0.52) | HTR1ADRD2HTR2CHRH1HTR2A | |
| SCHEMBL14359874 | 0.75 | CHRM2 (0.35) | HTR1ADRD2HTR2CHRH1HTR2A | |
| SCHEMBL7410588 | 0.74 | HTR1A (0.55) | HTR1ADRD2HTR2CHRH1HTR2A | |
| SCHEMBL6867510 | 0.73 | FAAH (0.46) | HTR1ADRD2KDM4ELMNACYP2C19 | |
| SCHEMBL13686223 | 0.73 | KDM4E (0.54) | HTR1ADRD2HTR2CHRH1HTR2A | |
| SCHEMBL13532479 | 0.72 | HTR1A (0.80) | HTR1ADRD2HTR2CHRH1HTR2A | |
| SCHEMBL14359067 | 0.72 | CHRM2 (0.36) | HTR1ADRD2HTR2CHRH1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013001498-A1 | AMIDOALKYLPIPERAZINYL DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES | ADAMED SP. Z O.O. (PL) | 2013-01-03 | — | — | WO | disclosed |