Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11075838 | 0.91 | SLC6A4 (0.37) | OPRM1OPRL1KCNH2SLC6A4SLC6A3 | |
| SCHEMBL11079009 | 0.85 | SLC6A4 (0.38) | OPRM1OPRL1KCNH2SLC6A4SLC6A3 | |
| SCHEMBL11077717 | 0.84 | OPRM1 (0.36) | OPRM1OPRL1KCNH2SLC6A4SLC6A3 | |
| SCHEMBL11072305 | 0.82 | HSD11B1 (0.32) | KCNH2SLC6A4SLC6A3HSD11B1SLC6A2 | |
| SCHEMBL4022665 | 0.78 | OPRM1 (0.44) | OPRM1OPRL1KCNH2SLC6A4SLC6A3 | |
| SCHEMBL11096384 | 0.77 | DRD3 (0.42) | OPRM1OPRL1SLC6A4 | |
| Hydrochloric Acid SCHEMBL11098093 | 0.77 | OPRM1 (0.42) | OPRM1OPRL1KCNH2SLC6A4SLC6A3 | |
| SCHEMBL11073309 | 0.76 | SLC6A4 (0.31) | OPRM1OPRL1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL11070525 | 0.76 | SLC6A4 (0.45) | OPRM1OPRL1KCNH2SLC6A4SLC6A3 | |
| Ethylene SCHEMBL11079292 | 0.75 | OPRM1 (0.41) | OPRM1OPRL1KCNH2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4460604-A | ANALGESICS, NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1984-07-17 | — | — | US | disclosed |
| US-4447454-A | Analgetic compounds, compositions and process of treatment | THE UPJOHN COMPANY (US) | 1984-05-08 | — | — | US | disclosed |
| US-4180584-A | ANALGESIC; NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4113866-A | ANALGETIC COMPOUNDS, COMPOSITIONS AND PROCESS OF TREATMENT | THE UPJOHN COMPANY (US) | 1978-09-12 | — | — | US | disclosed |
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | disclosed |