Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 6/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9630168 | 0.81 | TDP2 (0.38) | SMN1; SMN2ALDH1A1PTGS2PTGS1CRBN | |
| SCHEMBL11079732 | 0.81 | PDE3B (0.49) | MAPK14CRBNDDB1PDE3BPDE3A | |
| SCHEMBL11083179 | 0.80 | CYP11B1 (0.52) | ALDH1A1PTGS2PTGS1CRBNPDE3B | |
| SCHEMBL11084887 | 0.79 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1LMNAPTGS2PTGS1 | |
| Biphenyl SCHEMBL7154019 | 0.77 | CRBN (0.58) | SRD5A1CFTRGOPCSMN1; SMN2NPC1 | |
| SCHEMBL9630888 | 0.74 | ALDH1A1 (0.38) | SMN1; SMN2ALDH1A1LMNAPTGS2PTGS1 | |
| SCHEMBL10338409 | 0.73 | KCNH2 (0.55) | CRBNDDB1KMT2APDE3BPDE3A | |
| Toluene SCHEMBL8371012 | 0.73 | CRBN (0.52) | SRD5A1SMN1; SMN2NPC1MAPK13MAPK12 | |
| SCHEMBL31678688 | 0.69 | PTGS2 (0.50) | SRD5A1CFTRGOPCSMN1; SMN2ALDH1A1 | |
| Succinimide SCHEMBL28635055 | 0.68 | CRBN (0.79) | SRD5A1SMN1; SMN2NPC1MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4508722-A | 1-Benzoyl-3-(arylpyridyl)urea compounds | ELI LILLY AND COMPANY (US) | 1985-04-02 | — | — | US | disclosed |
| US-4405552-A | INSECTICIDES | ELI LILLY AND COMPANY (US) | 1983-09-20 | — | — | US | disclosed |
| EP-0060071-A1 | Improvements in or relating to 1-benzoyl-3-(arylpyridyl)urea compounds | ELI LILLY AND COMPANY (US) | 1982-09-15 | — | — | EP | disclosed |