Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11080480 | 0.78 | POLB (0.50) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL11481516 | 0.72 | ALDH1A1 (0.33) | HTR1AADRA1DADRA1AADRA1BKMT2A | |
| SCHEMBL15264694 | 0.70 | ACHE (0.53) | HTR1AADRA1DADRA1AADRA1BKMT2A | |
| SCHEMBL11166442 | 0.68 | POLB (0.47) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL17626963 | 0.68 | TSHR (0.50) | KMT2AALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL1161927 | 0.67 | TDP1 (0.71) | KMT2AALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL29603881 | 0.67 | TDP1 (0.71) | KMT2AALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL11084843 | 0.67 | KMT2A (0.42) | HTR1AADRA1DADRA1AADRA1BKMT2A | |
| SCHEMBL8150115 | 0.66 | LMNA (0.53) | KMT2AALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL7611589 | 0.65 | MAPT (0.44) | KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4438116-A | Quinoxalinyloxy-amino-propanol compounds with blood pressure lowering and β-blocking properties, their use and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1984-03-20 | — | — | US | disclosed |