Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.33 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.33 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1098144 | 0.83 | CYP2A6 (0.49) | MEN1KMT2AAKT3ALDH1A1MAPT | |
| SCHEMBL15087871 | 0.83 | DPP4 (0.44) | MEN1KMT2AAKT3ALDH1A1MAPT | |
| SCHEMBL2975938 | 0.79 | MEN1 (0.40) | MEN1KMT2AAKT3ALDH1A1MAPT | |
| SCHEMBL2980443 | 0.79 | DKK1 (0.43) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL2977591 | 0.78 | SMN1; SMN2 (0.39) | MEN1KMT2ANPC1RAB9AAKT3 | |
| SCHEMBL4482126 | 0.78 | IKBKB (0.45) | MEN1KMT2AAKT3ALDH1A1MAPT | |
| SCHEMBL12653224 | 0.78 | LMNA (0.48) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL2984634 | 0.77 | AKT3 (0.40) | MEN1KMT2ANPC1RAB9AAKT3 | |
| SCHEMBL2984079 | 0.77 | ALDH1A1 (0.58) | MEN1KMT2ARAB9AALDH1A1MAPT | |
| SCHEMBL11990079 | 0.76 | AKT3 (0.45) | MEN1KMT2ANPC1RAB9AAKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170112846-A1 | OXYGEN LINKED PYRIMIDINE DERIVATIVES | CTI BIOPHARMA CORP. (US) | 2017-04-27 | — | — | US | disclosed |
| US-9573964-B2 | Oxygen linked pyrimidine derivatives | CTI BIOPHARMA CORP. (US) | 2017-02-21 | — | — | US | disclosed |
| US-20130172338-A1 | OXYGEN LINKED PYRIMIDINE DERIVATIVES | CELL THERAPEUTICS, INC. (US) | 2013-07-04 | — | — | US | disclosed |
| US-20120196855-A1 | OXYGEN LINKED PYRIMIDINE DERIVATIVES | S*BIO PTE LTD. (SG) | 2012-08-02 | — | — | US | disclosed |
| US-8153632-B2 | Oxygen linked pyrimidine derivatives | S*BIO PTE LTD. (SG) | 2012-04-10 | — | — | US | disclosed |
| US-20090075999-A1 | OXYGEN LINKED PYRIMIDINE DERIVATIVES | S*BIO PTE LTD. (SG) | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090075999-A1 | OXYGEN LINKED PYRIMIDINE DERIVATIVES | DPYD, TK2, TK1 | MEN1 4071/4885KMT2A 1784/4885NPC1 3990/4885 |
| US-20130172338-A1 | OXYGEN LINKED PYRIMIDINE DERIVATIVES | DPYD, TK2, TK1 | MEN1 4071/4885KMT2A 1784/4885NPC1 3990/4885 |
| US-20170112846-A1 | OXYGEN LINKED PYRIMIDINE DERIVATIVES | DPYD, TK2, TK1 | MEN1 4071/4885KMT2A 1784/4885NPC1 3990/4885 |
| US-20120196855-A1 | OXYGEN LINKED PYRIMIDINE DERIVATIVES | DPYD, TK2, TK1 | MEN1 4071/4885KMT2A 1784/4885NPC1 3990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.