Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 3/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.32 |
| ▸ | CLK1 | P49759 | 4/20 | 0.32 |
| ▸ | CLK2 | P49760 | 3/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.32 |
| ▸ | SREBF2 | Q12772 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.30 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.30 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1097916 | 0.85 | KMO (0.36) | KMOAAK1DYRK1ACLK4CLK1 | |
| SCHEMBL15087883 | 0.84 | DAO (0.37) | KMOAAK1DYRK1ACLK4CLK1 | |
| SCHEMBL1099663 | 0.76 | KMO (0.30) | KMO | |
| SCHEMBL1108279 | 0.73 | ALDH1A1 (0.37) | KMOAAK1SREBF2KDM4ELMNA | |
| SCHEMBL1097124 | 0.73 | KMO (0.36) | KMOAAK1CYP2A6ALDH1A1 | |
| SCHEMBL1108277 | 0.72 | DNMT1 (0.36) | CYP1A2CYP2E1CYP2C8CYP2D6CYP2A6 | |
| SCHEMBL1108271 | 0.71 | IDO1 (0.48) | KMODYRK1ACLK4CLK1DYRK1B | |
| SCHEMBL18179480 | 0.70 | KMO (0.45) | KMOAAK1KDM4EMAPTALDH1A1 | |
| SCHEMBL7544652 | 0.68 | KMO (0.69) | KMODYRK1ACLK4CLK1CLK2 | |
| SCHEMBL13294776 | 0.68 | MAPT (0.40) | KMOCLK4CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170112846-A1 | OXYGEN LINKED PYRIMIDINE DERIVATIVES | CTI BIOPHARMA CORP. (US) | 2017-04-27 | — | — | US | disclosed |
| US-9573964-B2 | Oxygen linked pyrimidine derivatives | CTI BIOPHARMA CORP. (US) | 2017-02-21 | — | — | US | disclosed |
| US-20130172338-A1 | OXYGEN LINKED PYRIMIDINE DERIVATIVES | CELL THERAPEUTICS, INC. (US) | 2013-07-04 | — | — | US | disclosed |
| US-20120196855-A1 | OXYGEN LINKED PYRIMIDINE DERIVATIVES | S*BIO PTE LTD. (SG) | 2012-08-02 | — | — | US | disclosed |
| US-8153632-B2 | Oxygen linked pyrimidine derivatives | S*BIO PTE LTD. (SG) | 2012-04-10 | — | — | US | disclosed |
| US-20090075999-A1 | OXYGEN LINKED PYRIMIDINE DERIVATIVES | S*BIO PTE LTD. (SG) | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090075999-A1 | OXYGEN LINKED PYRIMIDINE DERIVATIVES | DPYD, TK2, TK1 | KMO 1161/4885AAK1 996/4885DYRK1A 940/4885 |
| US-20130172338-A1 | OXYGEN LINKED PYRIMIDINE DERIVATIVES | DPYD, TK2, TK1 | KMO 1161/4885AAK1 996/4885DYRK1A 940/4885 |
| US-20170112846-A1 | OXYGEN LINKED PYRIMIDINE DERIVATIVES | DPYD, TK2, TK1 | KMO 1161/4885AAK1 996/4885DYRK1A 940/4885 |
| US-20120196855-A1 | OXYGEN LINKED PYRIMIDINE DERIVATIVES | DPYD, TK2, TK1 | KMO 1161/4885AAK1 996/4885DYRK1A 940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.