SCHEMBL11083004

SCHEMBL11083004

COc1cc2c(cc1C(C)c1ccccc1)OCO2

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.55
CYP3A4 P08684 1/20 0.55
CYP2D6 P10635 1/20 0.55
CYP2C9 P11712 1/20 0.55
ALOX15 P16050 1/20 0.55
CYP2C19 P33261 1/20 0.55
P4HB P07237 4/20 0.43
SMAD3 P84022 1/20 0.43
LMNA P02545 1/20 0.43
HPGD P15428 1/20 0.43
GAA P10253 1/20 0.42
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
STAT3 P40763 1/20 0.41
TP53 P04637 1/20 0.41
ALDH1A1 P00352 1/20 0.40
MAPT P10636 1/20 0.40
RECQL P46063 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
HTR1A P08908 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7709780 0.87 CYP3A4 (0.72) CYP1A2CYP3A4CYP2D6CYP2C9ALOX15
SCHEMBL11088971 0.82 ALOX15 (0.44) CYP1A2CYP3A4CYP2D6CYP2C9ALOX15
SCHEMBL11086745 0.81 ALOX15 (0.45) CYP1A2CYP3A4CYP2D6CYP2C9ALOX15
SCHEMBL11089475 0.80 HPGD (0.42) CYP1A2CYP3A4CYP2D6CYP2C9ALOX15
SCHEMBL11090694 0.80 ALOX15 (0.41) CYP1A2CYP3A4CYP2D6CYP2C9ALOX15
SCHEMBL15145035 0.79 LMNA (0.51) CYP1A2CYP3A4CYP2D6CYP2C9ALOX15
SCHEMBL11087697 0.78 CYP3A4 (0.69) CYP1A2CYP3A4CYP2D6CYP2C9ALOX15
SCHEMBL24598762 0.74 CYP1A2 (0.63) CYP1A2CYP3A4CYP2D6CYP2C9ALOX15
SCHEMBL11094276 0.73 CYP3A4 (0.62) CYP1A2CYP3A4CYP2D6CYP2C9ALOX15
SCHEMBL11091615 0.73 CYP3A4 (0.62) CYP1A2CYP3A4CYP2D6CYP2C9ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4482728-A ANTIFERTILITY AGENTS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) 1984-11-13 US disclosed
US-4357344-A Polybutylbenzylphenols and benzyl-3,4-methylenedioxybenzenes in insect population control THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) 1982-11-02 US disclosed
US-4342777-A GROWTH INHIBITOR FOR MOSQUITO LARVAE THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) 1982-08-03 US disclosed