Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11095524 | 0.81 | USP2 (0.49) | USP2KMT2AHPGDTSHRCYP1A2 | |
| SCHEMBL11063288 | 0.78 | KMT2A (0.64) | USP2KMT2AHPGDTSHRCYP1A2 | |
| SCHEMBL10923503 | 0.77 | KMT2A (0.46) | USP2KMT2AHPGDTSHRSMN1; SMN2 | |
| SCHEMBL11880062 | 0.77 | ABCB11 (0.32) | USP2 | |
| SCHEMBL11062786 | 0.75 | KMT2A (0.51) | USP2KMT2AHPGDTSHRCYP1A2 | |
| SCHEMBL8581144 | 0.74 | USP2 (0.44) | USP2KMT2AHPGDTSHRCYP1A2 | |
| SCHEMBL10880617 | 0.71 | USP2 (0.42) | USP2KMT2AHPGDTSHRCYP3A4 | |
| SCHEMBL11093155 | 0.71 | KMT2A (0.44) | USP2KMT2AHPGDTSHRCYP1A2 | |
| SCHEMBL7682322 | 0.70 | THRB (0.48) | USP2KMT2AHPGDTSHRCYP1A2 | |
| SCHEMBL11609918 | 0.69 | ALDH1A1 (0.41) | USP2HPGDTSHRL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4434175-A | 5-AROYL-PYRROLE ALKANOIC ACIDS | MERCK & CO., INC. (US) | 1984-02-28 | — | — | US | disclosed |
| EP-0072013-A1 | Pyrrole compounds as anti-inflammatory and analgesic agents | MERCK & CO. INC. (US) | 1983-02-16 | — | — | EP | disclosed |