Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11471436 | 0.87 | OPRL1 (0.56) | — | |
| SCHEMBL11077313 | 0.84 | KCNH2 (0.54) | DRD2DRD3KCNH2 | |
| Hydrochloric Acid SCHEMBL11084692 | 0.84 | ALDH1A1 (0.43) | DRD2ALDH1A1 | |
| SCHEMBL11471422 | 0.83 | SIGMAR1 (0.44) | ALDH1A1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL11074721 | 0.81 | POLB (0.45) | SIGMAR1 | |
| SCHEMBL11480366 | 0.81 | KMT2A (0.49) | DRD2KDM4EALDH1A1 | |
| SCHEMBL11463554 | 0.81 | BMPR1B (0.44) | DRD2DRD3KCNH2 | |
| Hydrochloric Acid SCHEMBL11077710 | 0.80 | KMT2A (0.48) | DRD2KDM4EALDH1A1 | |
| SCHEMBL11074971 | 0.80 | CXCR3 (0.46) | ALDH1A1 | |
| SCHEMBL11072810 | 0.80 | CXCR3 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4435419-A | Method of treating depression using azabicyclohexanes | AMERICAN CYANAMID COMPANY (US) | 1984-03-06 | — | — | US | disclosed |
| US-4231935-A | ANXIOLYTICS AND ANALGESICS | AMERICAN CYANAMID COMPANY (US) | 1980-11-04 | — | — | US | disclosed |
| US-4196120-A | 1,2-BIS(HYDROCARBYLSULFONYLOXY OR HALO METHYL)CYCLOPROPYLBENZENE, OPTICAL ACITIVITY ANALGESICS | AMERICAN CYANAMID COMPANY (US) | 1980-04-01 | — | — | US | disclosed |
| US-4131611-A | ANXIOLYTIC, ANALGESIC | AMERICAN CYANAMID COMPANY (US) | 1978-12-26 | — | — | US | disclosed |
| US-4088652-A | Acylazabicyclohexanes | AMERICAN CYANAMID COMPANY (US) | 1978-05-09 | — | — | US | disclosed |