Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.32 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.32 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11087057 | 0.77 | ABCB1 (0.35) | BRD4 | |
| SCHEMBL11275624 | 0.74 | DRD2 (0.31) | DRD2HSD11B1 | |
| SCHEMBL11086035 | 0.73 | GABRP (0.36) | — | |
| SCHEMBL11072826 | 0.71 | BRD4 (0.53) | BRD4SRD5A1SRD5A2DRD2 | |
| SCHEMBL11080658 | 0.70 | ACHE (0.36) | BRD4 | |
| SCHEMBL11087338 | 0.69 | DRD2 (0.44) | BRD4DRD2 | |
| SCHEMBL11083192 | 0.69 | BRD4 (0.48) | BRD4SRD5A1 | |
| SCHEMBL11080571 | 0.68 | HTR2C (0.40) | BRD4 | |
| SCHEMBL11088778 | 0.68 | BRD4 (0.38) | BRD4SRD5A1SRD5A2 | |
| SCHEMBL11078778 | 0.67 | BRD4 (0.37) | BRD4SRD5A1SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0024776-B1 | 4-PHENYL AND 5-PHENYL-1,4,5,6-TETRAHYDROPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES, AND PROCESS FOR PREPARING SAID DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4261995-A | DISORDERS OF CENTRAL NERVOUS SYSTEM AND CARDIOVASCULAR SYSTEM; HYPOTENSIVE | SYNTEX (U.S.A.) INC. (US) | 1981-04-14 | — | — | US | disclosed |
| EP-0024776-A1 | 4-Phenyl and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives, pharmaceutical compositions containing said derivatives, and process for preparing said derivatives | SYNTEX (U.S.A.) INC. (US) | 1981-03-11 | — | — | EP | disclosed |