Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 7/20 | 0.67 |
| ▸ | ADRA1D | P25100 | 6/20 | 0.67 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.67 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.67 |
| ▸ | DRD2 | P14416 | 4/20 | 0.67 |
| ▸ | DRD3 | P35462 | 4/20 | 0.67 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.67 |
| ▸ | HTR1A | P08908 | 2/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.67 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.67 |
| ▸ | HTR2A | P28223 | 2/20 | 0.67 |
| ▸ | HTR2B | P41595 | 2/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.67 |
| ▸ | HTR7 | P34969 | 1/20 | 0.67 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9127458 | 0.99 | ADRA1A (0.66) | ADRA1AADRA1DADRA1BADRB2DRD2 | |
| SCHEMBL11082691 | 0.95 | ADRA1A (0.59) | ADRA1AADRA1DADRA1BADRB2DRD2 | |
| SCHEMBL10953622 | 0.88 | ADRA1A (0.67) | ADRA1AADRA1DADRA1BADRB2DRD2 | |
| Hydrochloric Acid SCHEMBL9122629 | 0.87 | ADRA1A (0.66) | ADRA1AADRA1DADRA1BADRB2DRD2 | |
| SCHEMBL11083181 | 0.87 | ADRB2 (0.71) | ADRA1AADRA1DADRA1BADRB2DRD2 | |
| SCHEMBL13697580 | 0.85 | ADRA1A (0.80) | ADRA1AADRA1DADRA1BADRB2DRD2 | |
| SCHEMBL11474908 | 0.83 | ADRA1A (0.46) | ADRA1AADRA1DADRA1BADRB2DRD2 | |
| SCHEMBL11486580 | 0.83 | ADRB2 (0.77) | ADRA1AADRA1DADRA1BADRB2DRD2 | |
| SCHEMBL10952370 | 0.83 | ADRA1A (0.59) | ADRA1AADRA1DADRA1BADRB2DRD2 | |
| Hydrochloric Acid SCHEMBL9857980 | 0.82 | ADRB2 (0.75) | ADRA1AADRA1DADRA1BADRB2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0034432-B1 | SULFAMOYL-SUBSTITUTED PHENETHYLAMINE DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS, CONTAINING THEM | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1984-04-25 | — | — | EP | claimed |
| US-8017803-B2 | Process for the preparation of tamsulosin and intermediates thereof | HOVIONE INTER LTD. (CH) | 2011-09-13 | — | — | US | disclosed |
| US-20090234154-A1 | Process for the preparation of tamsulosin and intermediates thereof | HOVIONE INTER LTD. | 2009-09-17 | — | — | US | disclosed |
| US-20070142669-A1 | reacting o-ethoxyphenoxyethanol with sulfonyl chloride; reacting the sulfonate with (R)-(-)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide by condensation to produce Tamsulosin | SCINOPHARM TAIWAN LTD. | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090234154-A1 | Process for the preparation of tamsulosin and intermediates thereof | AVPR2, AVPR1B, TACR2 | ADRA1A 57/4885ADRA1D 31/4885ADRA1B 9/4885 |
| US-20070142669-A1 | reacting o-ethoxyphenoxyethanol with sulfonyl chloride; reacting the sulfonate with (R)-(-)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide by condensation to produce Tamsulosin | BPHL, REN, MME | ADRA1A 58/4885ADRA1D 69/4885ADRA1B 33/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.