Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 18/20 | 0.78 |
| ▸ | NR1I2 | O75469 | 7/20 | 0.71 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1108927 | 0.89 | HSD11B1 (0.76) | HSD11B1NR1I2HSD11B2 | |
| SCHEMBL1108779 | 0.88 | HSD11B1 (0.62) | HSD11B1NR1I2HSD11B2 | |
| SCHEMBL1108724 | 0.88 | HSD11B2 (0.76) | HSD11B1NR1I2HSD11B2 | |
| SCHEMBL1108787 | 0.88 | HSD11B1 (0.62) | HSD11B1NR1I2HSD11B2 | |
| SCHEMBL1108736 | 0.88 | HSD11B1 (0.78) | HSD11B1NR1I2HSD11B2 | |
| SCHEMBL1108761 | 0.88 | HSD11B1 (0.62) | HSD11B1NR1I2HSD11B2 | |
| SCHEMBL1108782 | 0.88 | HSD11B1 (0.68) | HSD11B1NR1I2HSD11B2 | |
| SCHEMBL1108781 | 0.88 | HSD11B1 (0.61) | HSD11B1NR1I2HSD11B2 | |
| SCHEMBL4531560 | 0.88 | HSD11B1 (1.00) | HSD11B1NR1I2HSD11B2 | |
| SCHEMBL1108925 | 0.87 | HSD11B1 (0.67) | HSD11B1NR1I2HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153631-B2 | Triazole compounds and uses related thereto | AMGEN INC. (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153631-B2 | Triazole compounds and uses related thereto | AMGEN INC. (US) | 2012-04-10 | — | — | US | disclosed |
| US-7683059-B2 | Triazole compounds and uses related thereto | AMGEN INC. (US) | 2010-03-23 | — | — | US | disclosed |
| US-20100062972-A1 | TRIAZOLE COMPOUNDS AND USES RELATED THERETO | AMGEN INC. | 2010-03-11 | — | — | US | disclosed |
| US-20100062972-A1 | TRIAZOLE COMPOUNDS AND USES RELATED THERETO | AMGEN INC. | 2010-03-11 | — | — | US | disclosed |
| US-20080249084-A1 | Triazole Compounds and Uses Related Thereto | AMGEN SF LLC | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100062972-A1 | TRIAZOLE COMPOUNDS AND USES RELATED THERETO | HSD11B1, HSD17B1, HSD17B3 | HSD11B1 1/4885NR1I2 211/4885HSD11B2 4/4885 |
| US-20080249084-A1 | Triazole Compounds and Uses Related Thereto | GPR119, CYP11B2, CYP11B1 | HSD11B1 41/4885NR1I2 606/4885HSD11B2 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.