Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | FLT3 | P36888 | 3/20 | 0.44 |
| ▸ | PLK4 | O00444 | 2/20 | 0.44 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.44 |
| ▸ | FLT4 | P35916 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | MST1R | Q04912 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6184759 | 0.89 | KMT2A (0.48) | GSK3BKDRFLT3PLK4NUAK1 | |
| SCHEMBL11083302 | 0.83 | PTGS1 (0.57) | KDRFLT3PLK4NUAK1FLT4 | |
| SCHEMBL11091390 | 0.83 | KDR (0.47) | KDRFLT3PLK4NUAK1FLT4 | |
| SCHEMBL11091670 | 0.83 | PTGS1 (0.57) | KDRFLT3PLK4NUAK1FLT4 | |
| SCHEMBL11092256 | 0.81 | PLK4 (0.64) | GSK3BKDRFLT3PLK4NUAK1 | |
| SCHEMBL11094421 | 0.80 | KIF11 (0.50) | KDRFLT3PLK4NUAK1FLT4 | |
| SCHEMBL3816794 | 0.74 | GSK3B (0.67) | GSK3BCYP1A2PTGS2 | |
| SCHEMBL5849713 | 0.74 | PKM (0.46) | KMT2AKDM4EPTGS2 | |
| SCHEMBL11089509 | 0.73 | CYP19A1 (0.52) | KDRFLT3PLK4NUAK1FLT4 | |
| SCHEMBL6188862 | 0.72 | KMT2A (0.79) | CYP1A2KMT2APTGS1KDM4EPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4443616-A | Production of 3-pyrrolin-2-ones | THE PURDUE FREDERICK COMPANY (US) | 1984-04-17 | — | — | US | disclosed |