Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 10/20 | 0.57 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 2/20 | 0.44 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.44 |
| ▸ | FLT4 | P35916 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11083302 | 1.00 | PTGS1 (0.57) | PTGS1GRM2PLK4NUAK1FLT4 | |
| SCHEMBL6184759 | 0.89 | KMT2A (0.48) | PTGS1PLK4NUAK1FLT4KDR | |
| SCHEMBL11091390 | 0.83 | KDR (0.47) | PTGS1PLK4NUAK1FLT4KDR | |
| SCHEMBL11089094 | 0.83 | GSK3B (0.45) | PTGS1PLK4NUAK1FLT4KDR | |
| SCHEMBL11094421 | 0.83 | KIF11 (0.50) | PTGS1PLK4NUAK1FLT4KDR | |
| SCHEMBL11086876 | 0.83 | PTGS1 (0.44) | PTGS1GRM2PLK4NUAK1FLT4 | |
| SCHEMBL11092256 | 0.81 | PLK4 (0.64) | PTGS1PLK4NUAK1FLT4KDR | |
| SCHEMBL5848641 | 0.74 | MAP2K4 (0.48) | PTGS1PTGS2KMT2A | |
| SCHEMBL7345190 | 0.74 | GRM2 (0.43) | PTGS1GRM2FLT3CLK4PTGS2 | |
| SCHEMBL11089509 | 0.73 | CYP19A1 (0.52) | PLK4NUAK1FLT4KDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4443616-A | Production of 3-pyrrolin-2-ones | THE PURDUE FREDERICK COMPANY (US) | 1984-04-17 | — | — | US | disclosed |