Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5849863 | 0.88 | ALDH1A1 (0.53) | PKMHTTKDM4ERECQLSMN1; SMN2 | |
| SCHEMBL5848641 | 0.88 | MAP2K4 (0.48) | PKMKDM4ERECQLSMN1; SMN2KMT2A | |
| SCHEMBL5848834 | 0.88 | PKM (0.42) | PKMHTTKDM4ERECQLSMN1; SMN2 | |
| SCHEMBL5849888 | 0.82 | MMP1 (0.41) | PKMKDM4ERECQLSMN1; SMN2KMT2A | |
| SCHEMBL5848008 | 0.81 | LMNA (0.44) | PKMKDM4ERECQLSMN1; SMN2HTR1A | |
| SCHEMBL5848446 | 0.81 | MAPK1 (0.42) | PKMHTTKDM4ERECQLSMN1; SMN2 | |
| SCHEMBL5848434 | 0.79 | PTGS2 (0.46) | KDM4ESMN1; SMN2KMT2APTGS2 | |
| SCHEMBL2178427 | 0.78 | KDM4E (0.68) | HTTKDM4ERECQLSMN1; SMN2KMT2A | |
| SCHEMBL11089094 | 0.74 | GSK3B (0.45) | KDM4EKMT2APTGS2 | |
| SCHEMBL14842266 | 0.72 | SMN1; SMN2 (0.75) | HTTKDM4ERECQLSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7112605-B2 | Sulfonyl-containing 3,4-diaryl-3-pyrrolin-2-ones, preparation method, and medical use thereof | Research Institute of Materia Medica Chinese Acadamy of Medical Sciences (CN) | 2006-09-26 | — | — | US | claimed |