Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 18/20 | 0.53 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 8/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1108939 | 0.85 | HSD11B1 (0.55) | HSD11B1HSD11B2NR1I2 | |
| SCHEMBL1108815 | 0.82 | HSD11B1 (0.67) | HSD11B1HSD11B2NR1I2 | |
| SCHEMBL1108803 | 0.81 | HSD11B1 (0.54) | HSD11B1HSD11B2NR1I2 | |
| SCHEMBL1108736 | 0.81 | HSD11B1 (0.78) | HSD11B1HSD11B2NR1I2 | |
| SCHEMBL1108937 | 0.80 | HSD11B1 (0.53) | HSD11B1HSD11B2NR1I2 | |
| SCHEMBL1108936 | 0.80 | HSD11B1 (0.52) | HSD11B1HSD11B2NR1I2 | |
| SCHEMBL1108934 | 0.79 | HSD11B1 (0.53) | HSD11B1HSD11B2NR1I2 | |
| SCHEMBL1108940 | 0.78 | HSD11B1 (0.58) | HSD11B1HSD11B2NR1I2 | |
| SCHEMBL1108935 | 0.77 | HSD11B1 (0.66) | HSD11B1HSD11B2NR1I2 | |
| SCHEMBL1108807 | 0.77 | HSD11B1 (0.78) | HSD11B1HSD11B2NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153631-B2 | Triazole compounds and uses related thereto | AMGEN INC. (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153631-B2 | Triazole compounds and uses related thereto | AMGEN INC. (US) | 2012-04-10 | — | — | US | disclosed |
| US-7683059-B2 | Triazole compounds and uses related thereto | AMGEN INC. (US) | 2010-03-23 | — | — | US | disclosed |
| US-7683059-B2 | Triazole compounds and uses related thereto | AMGEN INC. (US) | 2010-03-23 | — | — | US | disclosed |
| US-20100062972-A1 | TRIAZOLE COMPOUNDS AND USES RELATED THERETO | AMGEN INC. | 2010-03-11 | — | — | US | disclosed |
| US-20100062972-A1 | TRIAZOLE COMPOUNDS AND USES RELATED THERETO | AMGEN INC. | 2010-03-11 | — | — | US | disclosed |
| US-20080249084-A1 | Triazole Compounds and Uses Related Thereto | AMGEN SF LLC | 2008-10-09 | — | — | US | disclosed |
| US-20080249084-A1 | Triazole Compounds and Uses Related Thereto | AMGEN SF LLC | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100062972-A1 | TRIAZOLE COMPOUNDS AND USES RELATED THERETO | HSD11B1, HSD17B1, HSD17B3 | HSD11B1 1/4885HSD11B2 4/4885NR1I2 211/4885 |
| US-20080249084-A1 | Triazole Compounds and Uses Related Thereto | GPR119, CYP11B2, CYP11B1 | HSD11B1 41/4885HSD11B2 31/4885NR1I2 606/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.