Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 10/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11180957 | 0.94 | ALDH1A1 (0.39) | WDR5TP53HPGDHSD17B10ALDH1A1 | |
| SCHEMBL11097275 | 0.85 | WDR5 (0.46) | WDR5TP53HPGDHSD17B10ALDH1A1 | |
| SCHEMBL11093896 | 0.83 | WDR5 (0.42) | WDR5TP53HPGDHSD17B10ALDH1A1 | |
| SCHEMBL11193638 | 0.79 | ALDH1A1 (0.41) | WDR5TP53HPGDHSD17B10ALDH1A1 | |
| SCHEMBL11088975 | 0.76 | HPGD (0.57) | WDR5TP53HPGDHSD17B10ALDH1A1 | |
| SCHEMBL4090031 | 0.75 | HDAC1 (0.50) | WDR5TP53HPGDHSD17B10ALDH1A1 | |
| SCHEMBL11087009 | 0.73 | WDR5 (0.47) | WDR5TP53HPGDHSD17B10ALDH1A1 | |
| SCHEMBL11182694 | 0.71 | HSD17B10 (0.52) | TP53HPGDHSD17B10ALDH1A1NPC1 | |
| SCHEMBL2325818 | 0.70 | WDR5 (0.49) | WDR5TP53HPGDHSD17B10ALDH1A1 | |
| SCHEMBL14701710 | 0.69 | WDR5 (0.50) | WDR5TP53HPGDHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4482557-A | 3-Substituted-2-oxo-tetrahydro-pyrrol[1,2-a]pyrimidines having digitalis-like activity | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1984-11-13 | — | — | US | disclosed |
| US-4367229-A | 3-Substituted-tetrahydro-pyrrolo[1,2-a]pyrimidines and pharmaceutical compositions | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1983-01-04 | — | — | US | disclosed |