Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11093198 | 0.94 | LMNA (0.47) | LMNASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL10499478 | 0.91 | LMNA (0.51) | LMNASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL10498571 | 0.84 | LMNA (0.53) | LMNASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL10498859 | 0.83 | LMNA (0.51) | LMNASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL10498662 | 0.82 | ALDH1A1 (0.50) | LMNASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL10498609 | 0.81 | LMNA (0.51) | LMNASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL3048258 | 0.76 | KMT2A (0.56) | LMNASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL10465161 | 0.75 | ALDH1A1 (0.58) | LMNASMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL10498566 | 0.73 | KMT2A (0.53) | LMNASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL9382061 | 0.71 | KMT2A (0.66) | LMNASMN1; SMN2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0118138-A1 | ((4-(4-(4-Phenyl-1-piperazinyl)phenoxymethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazoles and 1H-1,2,4-triazoles | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-09-12 | — | — | EP | disclosed |