Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.63 |
| ▸ | MAOB | P27338 | 9/20 | 0.56 |
| ▸ | MAOA | P21397 | 6/20 | 0.56 |
| ▸ | AHR | P35869 | 2/20 | 0.53 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.53 |
| ▸ | KIF11 | P52732 | 1/20 | 0.52 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.49 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13282888 | 0.87 | EIF2AK2 (0.84) | EIF2AK2MAOBMAOAAHRPDK2 | |
| SCHEMBL11089100 | 0.86 | AHR (0.68) | EIF2AK2MAOBMAOAAHRPDK2 | |
| SCHEMBL5638486 | 0.86 | EIF2AK2 (0.61) | EIF2AK2MAOBAHRPDK2KIF11 | |
| SCHEMBL11094738 | 0.81 | MAOB (0.53) | EIF2AK2MAOBMAOAAHRPDK2 | |
| SCHEMBL3285782 | 0.80 | NPC1 (0.59) | MAOBMAOAAHRPDK2GRIA1 | |
| SCHEMBL4751126 | 0.79 | MAOB (0.78) | MAOBMAOAPDE3BPDE3A | |
| SCHEMBL3311667 | 0.79 | KIF11 (0.59) | MAOBMAOAKIF11PGRPDE3B | |
| SCHEMBL22904229 | 0.78 | MAOA (0.62) | EIF2AK2MAOBMAOA | |
| SCHEMBL31040124 | 0.78 | PDE3B (0.66) | EIF2AK2MAOBMAOAAHRPDK2 | |
| SCHEMBL20214 | 0.78 | PDE3B (0.66) | EIF2AK2MAOBMAOAAHRPDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8455529-B2 | Kinase inhibitors | ALLERGAN, INC. (US) | 2013-06-04 | — | — | US | disclosed |
| WO-2010075197-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2010-07-01 | — | — | WO | disclosed |
| WO-2008022013-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2008-02-21 | — | — | WO | disclosed |
| US-4472433-A | Phenoxyphenyl acetic acids and their medicinal use | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-09-18 | — | — | US | disclosed |
| EP-0008226-B1 | PHENYL-ALKANOIC ACID DERIVATIVES, THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-11-02 | — | — | EP | disclosed |
| EP-0008226-A2 | Phenyl-alkanoic acid derivatives, the preparation thereof and pharmaceutical compositions containing them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-02-20 | — | — | EP | disclosed |