Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 12/20 | 0.98 |
| ▸ | DRD2 | P14416 | 12/20 | 0.98 |
| ▸ | HTR2A | P28223 | 12/20 | 0.98 |
| ▸ | HTR7 | P34969 | 9/20 | 0.98 |
| ▸ | HTR6 | P50406 | 9/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.96 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.96 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.96 |
| ▸ | HPGD | P15428 | 2/20 | 0.96 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.96 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.96 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.96 |
| ▸ | HRH1 | P35367 | 2/20 | 0.96 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.96 |
| ▸ | LMNA | P02545 | 1/20 | 0.96 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.96 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.96 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.96 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.96 |
| ▸ | DRD1 | P21728 | 1/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trazodone SCHEMBL28167 | 0.98 | HTR1A (1.00) | HTR1ADRD2HTR2AHTR7HTR6 | |
| Trazodone SCHEMBL29390760 | 0.98 | HTR1A (1.00) | HTR1ADRD2HTR2AHTR7HTR6 | |
| Trazodone SCHEMBL29575935 | 0.97 | KDM4E (1.00) | HTR1ADRD2HTR2AHTR7HTR6 | |
| Trazodone SCHEMBL3402550 | 0.97 | KDM4E (1.00) | HTR1ADRD2HTR2AHTR7HTR6 | |
| Trazodone SCHEMBL28226073 | 0.97 | HTR1A (0.98) | HTR1ADRD2HTR2AHTR7HTR6 | |
| Trazodone SCHEMBL61754 | 0.97 | KDM4E (1.00) | HTR1ADRD2HTR2AHTR7HTR6 | |
| Trazodone SCHEMBL120883 | 0.96 | HTR1A (0.96) | HTR1ADRD2HTR2AHTR7HTR6 | |
| Trazodone SCHEMBL27570399 | 0.93 | DRD2 (0.90) | HTR1ADRD2HTR2AHTR7HTR6 | |
| Trazodone SCHEMBL8741340 | 0.92 | DRD2 (0.89) | HTR1ADRD2HTR2AHTR7HTR6 | |
| Trazodone SCHEMBL23145121 | 0.91 | HTR1A (0.87) | HTR1ADRD2HTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0025603-B1 | TRIAZOLO (4,3-A)PYRIDIN-3(2H)-ONES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Bristol-Myers Company (US) | 1983-11-02 | — | — | EP | claimed |
| EP-0025603-A1 | Triazolo (4,3-a)pyridin-3(2H)-ones, process for their preparation and pharmaceutical compositions containing them | Bristol-Myers Company (US) | 1981-03-25 | — | — | EP | claimed |
| US-4465683-A | TRIAZOLOPYRIDINONES | MEAD JOHNSON & COMPANY (US) | 1984-08-14 | — | — | US | disclosed |
| EP-0025603-A1 | Triazolo (4,3-a)pyridin-3(2H)-ones, process for their preparation and pharmaceutical compositions containing them | Bristol-Myers Company (US) | 1981-03-25 | — | — | EP | disclosed |