Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trazodone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 12/20 | 0.87 |
| ▸ | SLC6A4 known ✓ | P31645 | 3/20 | 0.87 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.87 |
| ▸ | HTR1A | P08908 | 12/20 | 0.87 |
| ▸ | DRD2 | P14416 | 12/20 | 0.87 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.87 |
| ▸ | HRH1 | P35367 | 3/20 | 0.87 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.87 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.87 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.87 |
| ▸ | HPGD | P15428 | 2/20 | 0.87 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.87 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.87 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.87 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.87 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.87 |
| ▸ | DRD1 | P21728 | 2/20 | 0.87 |
| ▸ | DRD4 | P21917 | 2/20 | 0.87 |
| ▸ | HRH2 | P25021 | 2/20 | 0.87 |
| ▸ | TACR1 | P25103 | 2/20 | 0.87 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trazodone SCHEMBL28167 | 0.93 | HTR1A (1.00) | HTR1ADRD2HTR2ASLC6A4ADRA1A | |
| Trazodone SCHEMBL29390760 | 0.93 | HTR1A (1.00) | HTR1ADRD2HTR2ASLC6A4ADRA1A | |
| Trazodone SCHEMBL3402550 | 0.92 | KDM4E (1.00) | HTR1ADRD2HTR2ASLC6A4ADRA1A | |
| Trazodone SCHEMBL28226073 | 0.92 | HTR1A (0.98) | HTR1ADRD2HTR2ASLC6A4ADRA1A | |
| Trazodone SCHEMBL29575935 | 0.92 | KDM4E (1.00) | HTR1ADRD2HTR2ASLC6A4ADRA1A | |
| Trazodone SCHEMBL61754 | 0.92 | KDM4E (1.00) | HTR1ADRD2HTR2ASLC6A4ADRA1A | |
| Trazodone SCHEMBL120883 | 0.91 | HTR1A (0.96) | HTR1ADRD2HTR2ASLC6A4ADRA1A | |
| SCHEMBL11089944 | 0.91 | HTR1A (0.98) | HTR1ADRD2HTR2ASLC6A4ADRA1A | |
| Trazodone SCHEMBL27570399 | 0.91 | DRD2 (0.90) | HTR1ADRD2HTR2ASLC6A4ADRA1A | |
| Trazodone SCHEMBL8741340 | 0.90 | DRD2 (0.89) | HTR1ADRD2HTR2ASLC6A4ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021061006-A1 | COMPOSITION FOR CORRECTING THE BEHAVIOUR OF CATS AND DOGS | Общество с ограниченной ответственностью "Научно-производственная компания "СКиФФ" | 2021-04-01 | — | — | WO | claimed |
| EP-3922250-A1 | COMPOSITION FOR CORRECTING THE BEHAVIOUR OF CATS AND DOGS | Obshestvo S Ogranichennoy Otvetstvennost'Yu "Nauchno-Proizvodstvennaya Kompaniya "Skiff" (RU) | 2021-12-15 | — | — | EP | disclosed |
| WO-2021061006-A1 | COMPOSITION FOR CORRECTING THE BEHAVIOUR OF CATS AND DOGS | Общество с ограниченной ответственностью "Научно-производственная компания "СКиФФ" | 2021-04-01 | — | — | WO | disclosed |
| WO-2021061006-A1 | COMPOSITION FOR CORRECTING THE BEHAVIOUR OF CATS AND DOGS | Общество с ограниченной ответственностью "Научно-производственная компания "СКиФФ" | 2021-04-01 | — | — | WO | disclosed |