Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | BLM | P54132 | 2/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.74 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.74 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | TYMS | P04818 | 1/20 | 0.61 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.52 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.46 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.44 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylenediamine SCHEMBL69119 | 0.97 | LMNA (0.78) | LMNABLMCYP3A4NFKB1PMP22 | |
| Ethylenediamine SCHEMBL4154009 | 0.94 | LMNA (0.74) | LMNABLMCYP3A4NFKB1PMP22 | |
| Ethylenediamine SCHEMBL15053407 | 0.94 | LMNA (0.74) | LMNABLMCYP3A4NFKB1PMP22 | |
| Ethylenediamine SCHEMBL5157252 | 0.94 | LMNA (0.74) | LMNABLMCYP3A4NFKB1PMP22 | |
| Ethylenediamine SCHEMBL10933099 | 0.91 | LMNA (0.78) | LMNABLMCYP3A4NFKB1PMP22 | |
| SCHEMBL8630078 | 0.88 | LMNA (0.83) | LMNABLMCYP3A4NFKB1PMP22 | |
| Putrescine SCHEMBL16241736 | 0.88 | LMNA (0.83) | LMNABLMCYP3A4NFKB1PMP22 | |
| SCHEMBL745120 | 0.88 | — | — | |
| SCHEMBL11095560 | 0.87 | TYMS (0.79) | LMNABLMCYP3A4NFKB1PMP22 | |
| SCHEMBL4524881 | 0.86 | LMNA (0.79) | LMNABLMCYP3A4NFKB1PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111484520-A | Ethylene diamine tetramethylene aluminum phosphonate flame retardant and preparation method and application thereof | 金发科技股份有限公司 | 2020-08-04 | — | — | CN | claimed |
| CN-111484520-A | Ethylene diamine tetramethylene aluminum phosphonate flame retardant and preparation method and application thereof | 金发科技股份有限公司 | 2020-08-04 | — | — | CN | disclosed |
| CN-104846674-A | High-efficiency textile printing and dyeing auxiliary | QINGDAO DEXI TUOCHUANG HIGH AND NEW TECHNOLOGY CO LTD | 2015-08-19 | — | — | CN | disclosed |
| US-4430369-A | ALUMINOSILICATE FIBERS, CERAMICS, MATS, ALKALI STABILIZATION, AMINE-PHOSPHONIC OR ALIPHATIC ACID CONDENSATION PRODUCT | NALCO CHEMICAL COMPANY (US) | 1984-02-07 | — | — | US | disclosed |