Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4098970 | 0.89 | KMT2A (0.46) | GAAKMT2AJAK2JAK1TYK2 | |
| Biclodil SCHEMBL1815631 | 0.89 | CYP1A2 (0.49) | CYP1A2KMT2ATYK2F2F10 | |
| SCHEMBL11274193 | 0.88 | BACE1 (0.42) | GAACYP1A2KMT2ATLR7BACE1 | |
| Biclodil SCHEMBL121552 | 0.87 | CYP1A2 (0.47) | CYP1A2KMT2ATYK2F2F10 | |
| SCHEMBL11089784 | 0.82 | L3MBTL1 (0.47) | CYP1A2TYK2POLBPTGS2 | |
| SCHEMBL11093150 | 0.82 | CYP1A2 (0.43) | CYP1A2KMT2ATYK2F2F10 | |
| SCHEMBL11582985 | 0.82 | HTT (0.40) | KMT2AJAK1TLR7CA12CA1 | |
| SCHEMBL11579586 | 0.82 | DRD2 (0.44) | CYP1A2KMT2AF2F10PLAU | |
| SCHEMBL4099006 | 0.82 | GAA (0.51) | GAACYP1A2POLB | |
| SCHEMBL11056409 | 0.82 | KMT2A (0.47) | GAACYP1A2KMT2AJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4446152-A | SUBSTITUTED PHENYLAMIDINOUREA | WILLIAM H. RORER, INC. (US) | 1984-05-01 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |