Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KLK1 | P06870 | 1/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.39 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biclodil SCHEMBL1815631 | 0.86 | CYP1A2 (0.49) | TYK2PDK1PDK2PDK3PDK4 | |
| SCHEMBL11583003 | 0.86 | PTGS2 (0.43) | PTGS2 | |
| Biclodil SCHEMBL121552 | 0.85 | CYP1A2 (0.47) | TYK2PDK1PDK2PDK3PDK4 | |
| SCHEMBL11578713 | 0.84 | SMN1; SMN2 (0.42) | L3MBTL1TYK2LMNA | |
| SCHEMBL11578620 | 0.84 | RIPK1 (0.42) | L3MBTL1HPGDPDK1PDK2PDK3 | |
| SCHEMBL11431335 | 0.83 | L3MBTL1 (0.47) | L3MBTL1PTGS2TYK2GBA1HPGD | |
| SCHEMBL11090448 | 0.82 | GAA (0.43) | PTGS2TYK2CYP1A2POLB | |
| SCHEMBL11884358 | 0.82 | L3MBTL1 (0.47) | L3MBTL1PTGS2TYK2GBA1HPGD | |
| SCHEMBL11579856 | 0.81 | MAPK1 (0.47) | L3MBTL1PTGS2TYK2GBA1HPGD | |
| SCHEMBL11579402 | 0.80 | ALDH1A1 (0.43) | PDK1PDK2PDK3PDK4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4446152-A | SUBSTITUTED PHENYLAMIDINOUREA | WILLIAM H. RORER, INC. (US) | 1984-05-01 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |