Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 3/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8351053 | 0.84 | OPRM1 (0.50) | OPRM1OPRL1OPRK1HDAC3HDAC1 | |
| SCHEMBL11091107 | 0.84 | HSD11B1 (0.41) | SLC6A4SLC6A3OPRM1OPRL1OPRK1 | |
| SCHEMBL11092884 | 0.84 | SLC6A4 (0.40) | SLC6A4SLC6A3OPRM1OPRL1OPRK1 | |
| SCHEMBL11067006 | 0.84 | SLC6A4 (0.44) | SLC6A4SLC6A3OPRM1OPRL1OPRK1 | |
| SCHEMBL735724 | 0.83 | MEN1 (0.57) | OPRM1OPRL1OPRK1MEN1CYP2C9 | |
| Hydrochloric Acid SCHEMBL11093542 | 0.81 | MEN1 (0.55) | OPRM1OPRL1OPRK1MEN1CYP2C9 | |
| Ethylene SCHEMBL11096036 | 0.81 | SLC6A3 (0.42) | SLC6A4SLC6A3OPRM1OPRL1OPRK1 | |
| SCHEMBL11091173 | 0.81 | OPRM1 (0.55) | SLC6A4SLC6A3OPRM1OPRL1HDAC3 | |
| SCHEMBL8353549 | 0.80 | OPRM1 (0.43) | OPRM1OPRL1OPRK1KMT2AHDAC3 | |
| SCHEMBL8353019 | 0.80 | OPRM1 (0.43) | OPRM1OPRL1OPRK1KMT2AHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | claimed |
| US-4460604-A | ANALGESICS, NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1984-07-17 | — | — | US | disclosed |
| US-4180584-A | ANALGESIC; NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | disclosed |