Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11096378 | 0.92 | RAPGEF4 (0.42) | LMNAALDH1A1POLBRAPGEF4NPC1 | |
| SCHEMBL11417465 | 0.86 | RAPGEF4 (0.37) | LMNAALDH1A1RAPGEF4MAPTGAA | |
| SCHEMBL11093189 | 0.83 | LMNA (0.37) | LMNAALDH1A1POLBRAPGEF4DRD2 | |
| SCHEMBL11257145 | 0.83 | ALDH1A1 (0.48) | LMNAALDH1A1POLBDRD2HTR2A | |
| SCHEMBL11091737 | 0.83 | ALDH1A1 (0.40) | LMNAALDH1A1POLBNPC1HTT | |
| SCHEMBL11248653 | 0.83 | HTT (0.55) | LMNAALDH1A1POLBRAPGEF4HTT | |
| SCHEMBL11246972 | 0.81 | HTT (0.34) | LMNAALDH1A1POLBRAPGEF4HTT | |
| SCHEMBL11256873 | 0.81 | SCN5A (0.36) | LMNAALDH1A1NPC1KDM4EMAPT | |
| SCHEMBL11095766 | 0.81 | P2RX1 (0.39) | ALDH1A1RAPGEF4KDM4EMAPTGAA | |
| SCHEMBL11266319 | 0.80 | HTT (0.39) | LMNAALDH1A1POLBRAPGEF4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4446152-A | SUBSTITUTED PHENYLAMIDINOUREA | WILLIAM H. RORER, INC. (US) | 1984-05-01 | — | — | US | disclosed |
| US-4326074-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4115564-A | Treatment of diarrhea with amidinoureas | WILLIAM H. RORER, INC. (US) | 1978-09-19 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |