Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.49 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11875015 | 0.87 | TSHR (0.54) | TSHRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL650144 | 0.86 | TSHR (0.52) | TSHRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11095759 | 0.85 | TSHR (0.55) | TSHRAGTR1AGTR2KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL11096396 | 0.82 | CASR (0.49) | AGTR1AGTR2KDM4EALDH1A1HPGD | |
| SCHEMBL8954292 | 0.81 | ALDH1A1 (0.49) | AGTR1AGTR2KDM4EALDH1A1HPGD | |
| SCHEMBL11092583 | 0.80 | TSHR (0.51) | TSHRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11091674 | 0.80 | TP53 (0.53) | AGTR1AGTR2ALDH1A1 | |
| SCHEMBL11095197 | 0.79 | AGTR1 (0.50) | AGTR1AGTR2 | |
| SCHEMBL9473802 | 0.78 | AGTR1 (0.51) | AGTR1AGTR2 | |
| SCHEMBL11090546 | 0.78 | ALDH1A1 (0.54) | AGTR1AGTR2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0028833-B1 | IMIDAZOLE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1984-01-25 | — | — | EP | disclosed |
| US-4340598-A | Hypotensive imidazole derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1982-07-20 | — | — | US | disclosed |
| EP-0028833-A2 | Imidazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1981-05-20 | — | — | EP | disclosed |