Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11088418 | 0.88 | CYP3A4 (0.47) | LTA4HALDH1A1SMN1; SMN2 | |
| SCHEMBL11093116 | 0.87 | ALDH1A1 (0.43) | LTA4HALDH1A1SMN1; SMN2 | |
| SCHEMBL11090169 | 0.86 | EGFR (0.48) | LTA4HLMNAL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL11390128 | 0.85 | ALOX15 (0.47) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL11094010 | 0.85 | KMT2A (0.43) | L3MBTL1ALDH1A1 | |
| SCHEMBL11095919 | 0.84 | KMT2A (0.44) | L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL11090280 | 0.82 | KMT2A (0.43) | L3MBTL1ALDH1A1 | |
| SCHEMBL21879787 | 0.81 | LMNA (0.54) | LTA4HLMNAL3MBTL1ALDH1A1NR1H4 | |
| SCHEMBL11082845 | 0.81 | KMT2A (0.41) | L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL11094819 | 0.80 | ALDH1A1 (0.44) | LTA4HALDH1A1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4486443-A | PROSTAGLANDIN-LIKE EFFECTS | BURROUGHS WELLCOME CO. (US) | 1984-12-04 | — | — | US | disclosed |
| EP-0001238-B1 | HYDANTOIN DERIVATIVES, THEIR SYNTHESIS, PHARMACEUTICAL FORMULATIONS AND INTERMEDIATES IN THEIR PREPARATION | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-07-04 | — | — | EP | disclosed |
| US-4262128-A | HAVING PROSTAGLANDIN-LIKE BIOLOGICAL PROPERTIES | BURROUGHS WELLCOME CO. (US) | 1981-04-14 | — | — | US | disclosed |