Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11095987 | 0.88 | LTA4H (0.61) | NPC1RAB9A | |
| SCHEMBL3191795 | 0.88 | NPC1 (0.46) | NPC1RAB9AATMLMNACYP2C9 | |
| SCHEMBL3191801 | 0.88 | NPC1 (0.46) | NPC1RAB9AATMLMNACYP2C9 | |
| SCHEMBL1683002 | 0.86 | RAB9A (0.58) | NPC1RAB9AATMLMNACYP2C9 | |
| SCHEMBL19037806 | 0.84 | LMNA (0.49) | NPC1RAB9AATMLMNACYP2C9 | |
| SCHEMBL17294909 | 0.82 | GAA (0.44) | NPC1RAB9AATMLMNACYP2C9 | |
| SCHEMBL17294908 | 0.82 | GAA (0.44) | NPC1RAB9AATMLMNACYP2C9 | |
| SCHEMBL17304924 | 0.82 | GAA (0.44) | NPC1RAB9AATMLMNACYP2C9 | |
| SCHEMBL16984754 | 0.81 | NPSR1 (0.68) | RAB9AHSD17B10POLBKMT2AMEN1 | |
| SCHEMBL9650037 | 0.80 | ALDH1A1 (0.70) | NPC1RAB9AATMCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4483988-A | Substituted derivatives of 4-t-alkoxycarbonyl-piperazin-2-ones | RICHARDSON MERRELL INC. (US) | 1984-11-20 | — | — | US | disclosed |
| US-4341698-A | Enkaphalin derivatives | RICHARDSON-MERRELL INC. (US) | 1982-07-27 | — | — | US | disclosed |