Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 11/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | AGER | Q15109 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11097385 | 0.99 | MAOB (0.41) | MAOBHRH3PRKDCAHRBCHE | |
| Bromide SCHEMBL11181029 | 0.94 | MAOB (0.43) | MAOBHRH3PRKDCAHRBCHE | |
| Hydrochloric Acid SCHEMBL11094609 | 0.84 | MAOB (0.40) | MAOBHRH3PRKDCAHRBCHE | |
| Bromide SCHEMBL11088735 | 0.83 | MAOB (0.42) | MAOBHRH3BCHEACHEKDM4E | |
| SCHEMBL11288733 | 0.81 | MAOB (0.42) | MAOBHRH3PRKDCBCHEACHE | |
| Bromide SCHEMBL11097110 | 0.81 | CHRNB2 (0.43) | MAOBHRH3PRKDCAHRACHE | |
| Hydrochloric Acid SCHEMBL11092182 | 0.80 | MAOB (0.42) | MAOBHRH3PRKDCBCHEACHE | |
| Hydrochloric Acid SCHEMBL11096484 | 0.80 | ACHE (0.41) | MAOBHRH3AHRBCHEACHE | |
| Bromide SCHEMBL11090702 | 0.79 | MAOB (0.39) | MAOBHRH3PRKDCBCHEACHE | |
| Bromide SCHEMBL11089271 | 0.79 | MAOB (0.40) | MAOBHRH3ACHEKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0057362-B1 | DIBENZOFURANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES | BASF Aktiengesellschaft (DE) | 1984-06-20 | — | — | EP | disclosed |
| US-4376776-A | Dibenzofuran derivatives and their use for controlling fungi | BASF AKTIENGESELLSCHAFT (DE) | 1983-03-15 | — | — | US | disclosed |