Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | TSPO | P30536 | 1/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3817959 | 0.85 | PTGS1 (0.54) | PTGS1LMNAL3MBTL1CTNNB1POLB | |
| SCHEMBL8875079 | 0.85 | PTGS1 (0.54) | PTGS1LMNAL3MBTL1CTNNB1POLB | |
| SCHEMBL1345669 | 0.85 | PTGS1 (0.54) | PTGS1LMNAL3MBTL1CTNNB1POLB | |
| SCHEMBL11094201 | 0.84 | CXCL8 (0.50) | PTGS1POLBPTGS2CXCL8MEN1 | |
| SCHEMBL27520138 | 0.84 | PTGS1 (0.53) | PTGS1LMNAL3MBTL1CTNNB1POLB | |
| SCHEMBL10937484 | 0.79 | PTGS1 (0.51) | PTGS1LMNAL3MBTL1PTGS2CXCL8 | |
| SCHEMBL11105530 | 0.78 | PTGS1 (0.48) | PTGS1LMNAL3MBTL1CTNNB1MEN1 | |
| SCHEMBL11105534 | 0.78 | PTGS1 (0.48) | PTGS1LMNAL3MBTL1CTNNB1MEN1 | |
| SCHEMBL27638955 | 0.77 | LTA4H (0.47) | PTGS1LMNAL3MBTL1CTNNB1POLB | |
| SCHEMBL694250 | 0.76 | SLC6A4 (0.44) | CTNNB1ADORA2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4391814-A | Derivatives of antiphlogistically effective carboxylic acids, their preparation and medicinal use | SCHERING AKTIENGESELLSCHAFT (DE) | 1983-07-05 | — | — | US | disclosed |
| EP-0054812-A1 | Derivatives of antiphlogistically active carboxylic acids, their preparation and medical application | SCHERING AKTIENGESELLSCHAFT (DE) | 1982-06-30 | — | — | EP | disclosed |