Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 13/20 | 0.43 |
| ▸ | AURKA | O14965 | 9/20 | 0.43 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10967697 | 0.84 | MAPT (0.62) | RPS6KB1AURKACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10970832 | 0.77 | ADORA3 (0.55) | MAPTMAPK1AURKBKMT2A | |
| SCHEMBL10967842 | 0.75 | IRAK4 (0.41) | CYP1A2CYP3A4CYP2D6MAPTMAPK1 | |
| SCHEMBL11101059 | 0.73 | L3MBTL1 (0.56) | MAPTMAPK1KMT2A | |
| SCHEMBL11093656 | 0.73 | KMT2A (0.44) | MAPTMAPK1KMT2APARP1 | |
| SCHEMBL5569470 | 0.71 | EGFR (0.58) | CYP1A2CYP3A4CYP2D6MAPK1CYP2C19 | |
| SCHEMBL5569253 | 0.70 | TTBK1 (0.59) | RPS6KB1AURKAMAPTMAPK1AURKB | |
| SCHEMBL5564469 | 0.69 | ABCG2 (0.55) | RPS6KB1AURKACYP3A4MAPTCYP2C19 | |
| SCHEMBL27405493 | 0.69 | LMNA (0.46) | RPS6KB1AURKAAURKB | |
| SCHEMBL11104458 | 0.68 | EGFR (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0030156-B1 | QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-03-21 | — | — | EP | disclosed |
| US-4429126-A | ANTIASTHMA | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-01-31 | — | — | US | disclosed |
| US-4377580-A | ANTIALLERGENIC AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-03-22 | — | — | US | disclosed |
| EP-0030156-A1 | Quinazoline derivatives, processes for their preparation and pharmaceutical compositions containing them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-06-10 | — | — | EP | disclosed |