Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 5/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.31 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.31 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15935912 | 0.83 | ADRA2A (0.41) | CYP19A1CALCRLEPHX2 | |
| SCHEMBL259592 | 0.75 | CRBN (0.44) | NPSR1CRBNDDB1CALCRL | |
| SCHEMBL260407 | 0.74 | CA9 (0.45) | CRBNCYP19A1CALCRLKMT2A | |
| SCHEMBL11073635 | 0.74 | TDP2 (0.47) | CALCRL | |
| SCHEMBL11072700 | 0.74 | OTUD7B (0.48) | — | |
| SCHEMBL13062459 | 0.74 | PARP1 (0.40) | HTTTSHRNPSR1CRBNCYP19A1 | |
| SCHEMBL11073395 | 0.71 | GAA (0.39) | CRBNKMT2A | |
| SCHEMBL11072706 | 0.70 | MLNR (0.38) | CRBNCYP19A1DDB1 | |
| SCHEMBL260824 | 0.70 | CRBN (0.53) | HTTCRBNKMT2A | |
| SCHEMBL278097 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4471124-A | DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1984-09-11 | — | — | US | disclosed |
| US-4307108-A | DIABETES | PFIZER INC. (US) | 1981-12-22 | — | — | US | disclosed |