Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 3/20 | 0.47 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.37 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.36 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19586472 | 0.89 | TDP2 (0.44) | TDP2CMA1AHRBRD4METAP1 | |
| SCHEMBL11071163 | 0.89 | TDP2 (0.44) | TDP2CMA1AHRBRD4METAP1 | |
| SCHEMBL15935912 | 0.81 | ADRA2A (0.41) | METAP1PARP10PARP11PARP1CALCRL | |
| SCHEMBL9958538 | 0.80 | TDP2 (0.46) | TDP2CMA1AHRBRD4METAP1 | |
| SCHEMBL260407 | 0.79 | CA9 (0.45) | TDP2PARP1CALCRL | |
| SCHEMBL259592 | 0.77 | CRBN (0.44) | TDP2AHRCALCRL | |
| SCHEMBL13062459 | 0.76 | PARP1 (0.40) | PARP1CALCRL | |
| SCHEMBL11072700 | 0.76 | OTUD7B (0.48) | TDP2METAP1 | |
| SCHEMBL13015179 | 0.76 | KIF11 (0.36) | TDP2CALCRL | |
| SCHEMBL1727271 | 0.75 | TDP2 (0.42) | TDP2CMA1AHRBRD4METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4471124-A | DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1984-09-11 | — | — | US | disclosed |
| US-4442114-A | COMPLICATIONS OF DIABETES | PFIZER INC. (US) | 1984-04-10 | — | — | US | disclosed |
| US-4307108-A | DIABETES | PFIZER INC. (US) | 1981-12-22 | — | — | US | disclosed |