SCHEMBL11096062

SCHEMBL11096062

CCCNc1nc(C#N)c(C#N)nc1-c1cccc(C)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSS P25774 1/20 0.44
CTSK P43235 1/20 0.44
KDM4E B2RXH2 8/20 0.43
ALDH1A1 P00352 7/20 0.43
HPGD P15428 5/20 0.43
L3MBTL1 Q9Y468 3/20 0.43
LMNA P02545 3/20 0.43
TDP1 Q9NUW8 2/20 0.43
NPSR1 Q6W5P4 1/20 0.43
TP53 P04637 1/20 0.43
RXFP1 Q9HBX9 1/20 0.43
RAB9A P51151 5/20 0.42
NPC1 O15118 4/20 0.42
GAA P10253 4/20 0.42
MAPT P10636 1/20 0.42
SMN1; SMN2 Q16637 4/20 0.38
TSHR P16473 2/20 0.38
HSD17B10 Q99714 2/20 0.38
MAPK1 P28482 1/20 0.38
GLA P06280 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11085923 0.91 CTSS (0.47) CTSSCTSKKDM4EALDH1A1HPGD
SCHEMBL11090728 0.87 CTSS (0.46) CTSSCTSKKDM4EALDH1A1HPGD
SCHEMBL11087127 0.86 ADORA1 (0.51) CTSSCTSKKDM4EALDH1A1HPGD
SCHEMBL11094919 0.86 ADORA1 (0.45) KDM4EALDH1A1HPGDL3MBTL1LMNA
SCHEMBL11093965 0.85 KDM4E (0.50) KDM4EALDH1A1HPGDL3MBTL1LMNA
SCHEMBL11089357 0.84 ERBB2 (0.44) KDM4EALDH1A1HPGDL3MBTL1LMNA
SCHEMBL19618066 0.80 PDE5A (0.48) KDM4EALDH1A1L3MBTL1TDP1NPSR1
SCHEMBL11090534 0.77 CTSS (0.49) CTSSCTSKKDM4EALDH1A1HPGD
SCHEMBL11090451 0.76 MAP4K4 (0.48) KDM4EALDH1A1HPGDL3MBTL1NPSR1
SCHEMBL11093293 0.76 ADORA1 (0.60) CTSSCTSKKDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4460403-A 2,3-Dicyano 6 phenyl pyrazine herbicides KYOWA GAS CHEMICAL INDUSTRY CO., LTD. (JP) 1984-07-17 US disclosed
US-4259489-A PREEMERGENCE AND POSTEMERGENCE HERBICIDES KYOWA GAS CHEMICAL INDUSTRY CO. LTD. (JP) 1981-03-31 US disclosed