Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | KLK1 | P06870 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11580418 | 0.89 | DRD2 (0.44) | MEN1KMT2AMAPTL3MBTL1POLB | |
| SCHEMBL11093150 | 0.89 | CYP1A2 (0.43) | MEN1KMT2AL3MBTL1CYP1A2PLAU | |
| SCHEMBL11582985 | 0.89 | HTT (0.40) | MEN1KMT2A | |
| SCHEMBL11578703 | 0.89 | CYP1A2 (0.33) | GAAKDM4EMEN1KMT2AMAPT | |
| SCHEMBL11578713 | 0.85 | SMN1; SMN2 (0.42) | GAAKDM4EMEN1KMT2AMAPT | |
| SCHEMBL11577888 | 0.84 | MEN1 (0.38) | GAAMEN1KMT2AMAPTPOLB | |
| SCHEMBL11581841 | 0.82 | ALDH1A1 (0.35) | GAAMEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL11582104 | 0.81 | GAA (0.41) | GAAKDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL11579182 | 0.81 | L3MBTL1 (0.53) | GAAKDM4EMEN1KMT2AMAPT | |
| SCHEMBL11578720 | 0.79 | GAA (0.47) | GAAMEN1KMT2AMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4446152-A | SUBSTITUTED PHENYLAMIDINOUREA | WILLIAM H. RORER, INC. (US) | 1984-05-01 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |