Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | CFTR | P13569 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.51 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11177118 | 0.94 | ALDH1A1 (0.61) | ALDH1A1HSD17B10KDM4ENPC1KMT2A | |
| SCHEMBL4783720 | 0.72 | HPGD (0.91) | ALDH1A1HSD17B10KDM4ENPC1KMT2A | |
| SCHEMBL18708483 | 0.72 | RAB9A (0.49) | ALDH1A1HSD17B10KDM4ENPC1KMT2A | |
| SCHEMBL11092210 | 0.71 | SMN1; SMN2 (0.45) | ALDH1A1HSD17B10KDM4ENPC1KMT2A | |
| SCHEMBL4785098 | 0.71 | HPGD (0.94) | ALDH1A1HSD17B10KDM4ENPC1KMT2A | |
| SCHEMBL4783422 | 0.71 | HPGD (0.94) | ALDH1A1HSD17B10KDM4ENPC1KMT2A | |
| SCHEMBL11090827 | 0.71 | ALDH1A1 (0.43) | ALDH1A1HSD17B10KDM4ENPC1KMT2A | |
| SCHEMBL1750353 | 0.71 | L3MBTL1 (0.49) | ALDH1A1HSD17B10KDM4ENPC1KMT2A | |
| SCHEMBL11096311 | 0.69 | CYP11B1 (0.45) | ALDH1A1HSD17B10KDM4ENPC1KMT2A | |
| SCHEMBL11087355 | 0.69 | ALDH1A1 (0.37) | ALDH1A1HSD17B10NPC1HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4482557-A | 3-Substituted-2-oxo-tetrahydro-pyrrol[1,2-a]pyrimidines having digitalis-like activity | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1984-11-13 | — | — | US | disclosed |
| US-4367229-A | 3-Substituted-tetrahydro-pyrrolo[1,2-a]pyrimidines and pharmaceutical compositions | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1983-01-04 | — | — | US | disclosed |