Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11092953 | 0.86 | HTR2A (0.49) | HTR2ASLC6A4ATMKCNH2PTGS2 | |
| SCHEMBL11094079 | 0.86 | CYP3A4 (0.50) | HTR2ASLC6A4KCNH2CYP3A4CYP2D6 | |
| SCHEMBL11092566 | 0.85 | TSHR (0.44) | SLC6A4SMN1; SMN2TBXAS1PKMCYP2D6 | |
| SCHEMBL11084291 | 0.84 | SLC6A4 (0.47) | HTR2ASLC6A4HTTKCNH2CYP2C19 | |
| SCHEMBL11091259 | 0.84 | HTR2A (0.47) | HTR2ASLC6A4 | |
| SCHEMBL11087036 | 0.84 | HTR2A (0.43) | HTR2ASLC6A4CYP3A4 | |
| SCHEMBL11085687 | 0.83 | DHFR (0.38) | SLC6A4TBXAS1PKMCHEK1NLRP3 | |
| SCHEMBL11089498 | 0.82 | TBXAS1 (0.45) | HTTTBXAS1PKMCHEK1TDP1 | |
| SCHEMBL11090842 | 0.81 | KMT2A (0.43) | HTR2ASLC6A4ATMHTTPTGS2 | |
| SCHEMBL11092614 | 0.78 | CXCL8 (0.51) | TBXAS1PKML3MBTL1NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4472433-A | Phenoxyphenyl acetic acids and their medicinal use | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-09-18 | — | — | US | disclosed |
| EP-0008226-B1 | PHENYL-ALKANOIC ACID DERIVATIVES, THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-11-02 | — | — | EP | disclosed |
| EP-0008226-A2 | Phenyl-alkanoic acid derivatives, the preparation thereof and pharmaceutical compositions containing them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-02-20 | — | — | EP | disclosed |