Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.52 |
| ▸ | ADH5 | P11766 | 8/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11096275 | 0.86 | PDE3B (0.55) | PDE3BPDE3AADH5MEN1ALOX15 | |
| SCHEMBL11101037 | 0.83 | PDE3B (0.52) | PDE3BPDE3AADH5MEN1ALOX15 | |
| SCHEMBL11099862 | 0.81 | PDE3B (0.50) | PDE3BPDE3AADH5MEN1ALOX15 | |
| SCHEMBL11100354 | 0.79 | PDE3B (0.48) | PDE3BPDE3AADH5MEN1ALOX15 | |
| SCHEMBL11101040 | 0.78 | PDE3B (0.57) | PDE3BPDE3AADH5MEN1ALOX15 | |
| SCHEMBL7290528 | 0.68 | PDE3B (1.00) | PDE3BPDE3AADH5MEN1ALOX15 | |
| SCHEMBL2533488 | 0.68 | TSHR (0.84) | PDE3BPDE3AADH5MEN1ALOX15 | |
| SCHEMBL19186987 | 0.67 | KMT2A (0.70) | PDE3BPDE3AADH5MEN1ALOX15 | |
| SCHEMBL2532397 | 0.66 | LMNA (0.78) | ADH5MEN1ALOX15TSHRKMT2A | |
| SCHEMBL11097731 | 0.66 | NPC1 (0.50) | PDE3BPDE3AADH5MEN1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0122419-A2 | Substituted 3-mercaptopyridazines, their 3-alkylthio derivatives and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-10-24 | — | — | EP | disclosed |